Sodium aminodihydrophthalazinedione in the complex therapy of patients with alcohol dependence

Sodium aminodihydrophthalazinedione in the complex therapy of patients with alcohol dependence

 

Authors

 

E.V. Epimakhova

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

I.V. Voevodin

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

T.P. Vetlugina

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

N.I. Kisel

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

V.D. Prokopieva

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

R.I. Bedarev

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

A.F. Abolonin

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

N.A. Bokhan

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation; Federal State Budgetary Educational Institution of Higher Education “Siberian State Medical University” of the Ministry of Health of the Russian Federation, Tomsk, Russian Federation

 

https://doi.org/10.26617/1810-3111-2025-3(128)-60-68

 

Journal: Siberian Herald of Psychiatry and Addiction Psychiatry. 2025; 3 (128):  60-68.

 

Abstract

Background. Chronic alcohol consumption reduces the number of innate immune cells (NK cells), weakens the body's immune defense, and impairs the effectiveness of alcohol dependence (AD) treatment. Including drugs that optimize immune regulation in the treatment complex is rational and justified. Objective: to study the effect of adjuvant therapy with the inclusion of sodium aminodihydrophthalazinedione in the rehabilitation complex on NK cells and clinical parameters of patients with alcohol dependence. Materials and Methods. At the Department of Addictive States of the Mental Health Research Institute of Tomsk National Research Medical Center, we examined 65 male patients with an ICD-10 diagnosis of “Mental and behavioral disorders due to alcohol use (dependence syndrome ‒ F10.21 and withdrawal syndrome ‒ F10.30)” with an average disease duration of 15.0±9.5 years. Patients of the main group (n=40) were prescribed the immunomodulator sodium aminodihydrophthalazinedione (Galavit®) at a dose of 100 mg/day for 10 days in addition to standard therapy on days 2-3 of treatment. Patients of the comparison group (n=25) received standard therapy. Clinical and biological studies were conducted dynamically: point 1 ‒ on days 2-3 of treatment, point 2 ‒ after 14-17 days of therapy. NK cell phenotyping was performed in whole blood using a BD Facs Calibur flow cytometer. To assess the clinical condition of patients, the following were used: Hospital Anxiety and Depression Scale (HADS), Quantified Scale of Comprehensive Assessment of Psychopathological Disorders in Remission (QRSOPRR), Pennsylvania Alcohol Craving Scale (PACS). Results. At point 1, a statistically significant decrease in the number of NK cells was observed in patients in both groups compared to the control (25 healthy men). During therapy, an increase in the number of NK cells was noted in the main group of patients at point 2 compared to point 1. The overall clinical effect was more pronounced in the main group, with the most significant being the normalization of the anxiety index. Conclusion. Complex treatment with the inclusion of sodium aminodihydrophthalazinedione increases the number of NK cells in the blood of patients with AD and improves the quality of remission formation, including through a reduction in anxiety symptoms, as well as an improvement in the general condition of patients.

 

Keywords: alcohol dependence, alcoholism, innate immunity, NK-cells, sodium aminodihydrophthalazinedione, Galavit®, post-abstinence state, remission.

 

Article (pdf)

 

Contacts

 

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Materials  

For citation: Epimakhova E.V., Voevodin I.V., Vetlugina T.P., Kisel N.I., Prokopieva V.D., Bedarev R.I., Abolonin A.F., Bokhan N.A. Sodium aminodihydrophthalazinedione in the complex therapy of patients with alcohol dependence. Siberian Herald of Psychiatry and Addiction Psychiatry.2025; 3 (128): 60-68. https://doi.org/10.26617/1810-3111-2025-3(128)-60-68

 

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