Study of genetic polymorphisms of neurotransmitter systems of the brain in social orphans with psychopathological disorders

Study of genetic polymorphisms of neurotransmitter systems of the brain in social orphans with psychopathological disorders

 

Authors

 

E.A. Bodagova

Federal State Budgetary Educational Institution of Higher Education “Chita State Medical Academy” of the Ministry of Health of the Russian Federation, Chita, Russian Federation

N.V. Govorin

Federal State Budgetary Educational Institution of Higher Education “Chita State Medical Academy” of the Ministry of Health of the Russian Federation, Chita, Russian Federation

 

https://doi.org/10.26617/1810-3111-2024-1(122)-5-17

 

Journal: Siberian Herald of Psychiatry and Addiction Psychiatry. 2024; 1 (122):  5-17.

 

Abstract

Background.The pupils of boarding schools have extremely negative indices of mental and physical health, in contrast to children living in two-parent families. In the structure of the incidence of mental disorders, psychopathological disorders are at the forefront. The reasons for the development of mental disorders are not only environmental and social factors, but also genetic predisposition. A number of certain polymorphisms in the genes of the dopamine and serotonin neurotransmitter systems of the brain have pathogenetic significance in the formation of emotional and behavioral disorders. Therefore, today, the study of polymorphisms in genes of the neurotransmitter systems of the brain remains relevant, especially in the framework of studying the health of children left without parental care. Objective: to study the contribution of polymorphic variants of genes (TPH1, MAOA, HTR2A, DRD4, COMT, DBH, DRD2) of the neurotransmitter systems of the brain to the development of psychopathological disorders in children left without parental care in the Trans-Baikal Territory. Materials and Methods.A clinical and psychopathological examination of 516 pupils from Centers for Assistance to Children Without Parental Care was carried out. Psychometric diagnostics were carried out using standardized screening methods: Spielberger-Hanin, M. Kovacs, Bass-Darki tests. Mental and behavioral disorders were diagnosed according to the ICD-10 criteria. Two groups of children and adolescents aged 10-17 years were formed: the main group ‒ those left without parental care (n=400), the control group ‒ living in two-parent families (n=100). Subsequently, molecular genetic typing of polymorphic gene variants was performed: rs1800532 TPH1 (A218C), rs6323 MAOA (R297R), rs6313 HTR2A (T102C), rs1800955 DRD4 (C-521T), rs4680 COMT (G472A), rs1611115 DBH (C- 1021T), rs1800497 DRD2 (Taq1A), the frequencies of genotypes and alleles of these genes were determined. Results.It was established that polymorphic variants of the genes rs1800532 TPH1 (A218C), rs4680 COMT (G472A), rs1800497 DRD2 (Taq1A) and rs1611115 DBH (C-1021T) were associated with psychopathological disorders. In the group of social orphans with heightened anxiety, aggressiveness and criminal behavior, the frequency of occurrence of alleles and genotypes of polymorphic variants of the genes rs1800532 TPH1 (A218C), rs4680 COMT (G472A) and rs1611115 DBH (C-1021T) was statistically significantly (p<0.05) higher than in the control group. It was also found that the rs1800497 polymorphic variant of DRD2 (Taq1A) was  associated with anxiety.

 

Keywords: children left without parental care, social orphans, gene polymorphism, psychopathological disorders.

 

Article (pdf)

 

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Materials  

For citation: Bodagova E.A., Govorin N.V. Study of genetic polymorphisms of neurotransmitter systems of the brain in social orphans with psychopathological disorders.Siberian Herald of Psychiatry and Addiction Psychiatry.2024; 1 (122): 5-17. https://doi.org/10.26617/1810-3111-2024-1(122)-5-17

 

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