The relationship between Alzheimer's disease and skin diseases (research and analysis of literature)

The relationship between Alzheimer's disease and skin diseases (research and analysis of literature)

 

Authors

 

A.P. Sidenkova

1 Federal State Budgetary Educational Institution of Higher Education “Ural State Medical University” of the Ministry of Health of the Russian Federation, Yekaterinburg, Russian Federation

N.Yu. Vazhenina

S.V. Nudelman Center for Cosmetology and Plastic Medicine,Yekaterinburg, Russian Federation

 

https://doi.org/10.26617/1810-3111-2026-1(130)-116-130

 

Journal: Siberian Herald of Psychiatry and Addiction Psychiatry. 2026; 1 (130):  116-130.

 

Abstract

Due to the growing proportion of elderly people in the population, prevalence of age-associated diseases is increasing, with Alzheimer's disease (AD) occupying a leading place. The frequent comorbidity of AD with skin diseases, as well as the shared embryonic origin of the epidermal layer of the skin and the brain, suggests the involvement of the epidermis in common pathogenetic mechanisms underlying their development. Objective: to analyze scientific publications investigating the relationship between skin diseases localized to the epidermis and the occurrence of AD, and to explore the potential for developing non-invasive diagnostic methods for AD. Material and Methods. The study materials included scientific publications by Russian and foreign authors on the topic of the paper. General scientific methods were used: an objective analysis of modern scientific literature on the research problem, as well as generalization, comparison, and systematization of theoretical data on the cognitive continuum. Information search was conducted using keywords. Changes in the epidermal layer of the skin in patients with AD differ from normal age-associated changes occurring in the epidermis. Peripheral tissues originating from the same embryonic layer as the brain (such as the buccal epithelium and epidermal layer of the skin) represent potential non-invasive biomarkers of AD.

 

Keywords: Alzheimer's disease, dementia, cognitive impairment, skin, epidermal layer of the skin, epidermis, buccal epithelium, ectoderm.

 

Article (pdf)

 

Contacts

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Materials  

For citation: Sidenkova A.P., Vazhenina N.Yu. The relationship between Alzheimer's disease and skin diseases (research and analysis of literature). Siberian Herald of Psychiatry and Addiction Psychiatry.2026, 1 (130): 116-130. https://doi.org/10.26617/1810-3111-2026-1(130)-116-130

 

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