Associations of polymorphic variants of circadian system genes with the severity of psychopathological symptoms of schizophrenia

Associations of polymorphic variants of circadian system genes with the severity of psychopathological symptoms of schizophrenia

 

Authors

 

V.R. Gashkarimov

State Budgetary Healthcare Institution of the Republic of Bashkortostan “Republican Clinical Psychiatric Hospital”, Ufa, Bashkortostan, Russian Federation

E.R. Kunafina

Federal State Budgetary Educational Institution of Higher Education “Bashkir State Medical University” of the Ministry of Health of the Russian Federation, Ufa, Bashkortostan, Russian Federation

L.A. Selina

Federal State Budgetary Educational Institution of Higher Education “Ufa University of Science and Technology”, Ufa, Bashkortostan, Russian Federation

D.Kh. Afzaletdinova

State Budgetary Healthcare Institution of the Republic of Bashkortostan “Republican Clinical Psychiatric Hospital”, Ufa, Bashkortostan, Russian Federation; Federal State Budgetary Educational Institution of Higher Education “Bashkir State Medical University” of the Ministry of Health of the Russian Federation, Ufa, Bashkortostan, Russian Federation

R.R. Enikeev

Federal State Healthcare Institution “Medical Unit of the Ministry of Internal Affairs of Russia for the City of Moscow”, Moscow, Russian Federation

R.R. Romanova

State Budgetary Healthcare Institution of the Republic of Bashkortostan “Republican Clinical Psychiatric Hospital”, Ufa, Bashkortostan, Russian Federation

A.F. Maksyutova

Federal State Budgetary Educational Institution of Higher Education “Bashkir State Medical University”

of the Ministry of Health of the Russian Federation, Ufa, Bashkortostan, Russian Federation

A.R. Asadullin

Federal State Budgetary Educational Institution of Higher Education “Bashkir State Medical University”

of the Ministry of Health of the Russian Federation, Ufa, Bashkortostan, Russian Federation; Federal State Budgetary Educational Institution of Higher Education “Saratov State Medical University named after V.I. Razumovsky” of the Ministry of Health of the Russian Federation, Saratov, Russian Federation

 

https://doi.org/10.26617/1810-3111-2026-1(130)-29-36

 

Journal: Siberian Herald of Psychiatry and Addiction Psychiatry. 2026; 1 (130):  29-36.

 

Abstract

Rationale. It is known from the literature that the severity of circadian dysregulation is associated with greater severity of psychopathological symptoms and a decrease in the quality of life of patients with schizophrenia. Evaluation of associations of polymorphic variants of the circadian system genes with the severity of schizophrenia symptoms will allow us to approach biologically based stratification of patients and personalize therapeutic approaches. Objective. To identify associations of polymorphic variants of the MTNR1A (rs34532313), MTNR1B (rs10830963), CLOCK (rs801260), PER2 (rs934945) genes with the severity of psychopathological symptoms of schizophrenia. Methodology and Research Methods. The final sample included 390 patients with a verified diagnosis according to the ICD-10 criteria: paranoid schizophrenia (F20.0). The PANSS scale was used to quantitatively assess the severity of psychopathological symptoms in patients with schizophrenia. Genotyping of polymorphisms was carried out using the polymerase chain reaction method in real time. Comparison of quantitative indicators between independent samples was carried out using the Kruskal-Wallis test, subsequently, a regression model was constructed during the analysis. Results. Carriage of the TC genotype of the polymorphic variant of the CLOCK gene rs1801260 was associated with a lower score on item P3 Hallucinatory behavior of the PANSS scale. Conclusion. The heterozygous allelic variant TC rs1801260 CLOCK can be considered a protective factor in relation to the severity of hallucinatory behavior in people with schizophrenia. Given the small effect size, the result should be interpreted as hypothesis-forming, requiring verification and in-depth study in future studies.

 

Keywords: schizophrenia, positive symptoms, negative symptoms, CLOCK gene.

 

Article (pdf)

 

Contacts

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Materials  

For citation: Gashkarimov V.R., Kunafina E.R., Selina L.A., Afzaletdinova D.Kh., Enikeev R.R., Romanova R.R., Maksyutova A.F., Asadullin A.R. Associations of polymorphic variants of circadian system genes with the severity of psychopathological symptoms of schizophrenia. Siberian Herald of Psychiatry and Addiction Psychiatry.2026; 1 (130): 29-36. https://doi.org/10.26617/1810-3111-2026-1(130)-29-36

 

 

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