Mental disorders in the pathology of liver and biliary tract (literature review)

Mental disorders in the pathology of liver and biliary tract (literature review)

 

Authors

 

I.E. Kupriyanova

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

K.I. Chuikova

Federal State Budgetary Educational Institution of Higher Education “Siberian State Medical University”, Tomsk, Russian Federation

E.I. Petrova

Federal State Budgetary Educational Institution of Higher Education “Siberian State Medical University”, Tomsk, Russian Federation

T.V. Shushpanova

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation; Tomsk Research Institute of Balneology and Physiotherapy ‒ branch of “Federal Scientific and Clinical Center of Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency”, Tomsk, Russian Federation

D.M. Davaa

Federal State Budgetary Educational Institution of Higher Education “Siberian State Medical University”, Tomsk, Russian Federation

Guzyal Tair

Federal State Budgetary Educational Institution of Higher Education “Siberian State Medical University”, Tomsk, Russian Federation

 

https://doi.org/10.26617/1810-3111-2025-2(127)-98-108

 

Journal: Siberian Herald of Psychiatry and Addiction Psychiatry. 2025; 2 (127):  98-108.

 

Abstract

Background. Among liver diseases, a key position belongs to acute and chronic viral hepatites, among which hepatites B and C are currently the most common ones. The lack of appropriate treatment for chronic hepatitis often provokes cirrhosis and, in some cases, liver cancer. Incidence rate of liver and biliary tract diseases tends to grow constantly. Asthenic, anxiety and depressive disorders accompany this somatic pathology. Stress and anxiety can increase the perception of pain and discomfort, disrupting socio-psychological functioning. Psychopharmacotherapy of these disorders is especially difficult, since the metabolic functions of the liver are significantly reduced. Objective.To determine the relationship between mental disorders and liver, and biliary tract diseases, to identify the features of the clinical picture, and the possibilities of psychopharmacotherapy. Materials and Methods. The information search was carried out empirically using the Russian Science Citation Index, Web of Science and Scopus databases. Results. Liver and biliary tract diseases (opisthorchiasis) are associated with constant physical ailments that can reduce the quality of life and lead to psychoemotional-stress response, mental nonpsychotic disorders. The possibilities of antidepressant therapy for patients with metabolic liver diseases are considered. Conclusion. Liver and biliary tract diseases are accompanied by psychopathological symptoms characterized by asthenic syndrome, psychovegetative manifestations, neurotic states, mood and cognitive disorders. Support from mental health professionals, timely adequate pharmacotherapy can significantly improve the quality of life of these patients.

 

Keywords: liver and biliary tract diseases, opisthorchiasis, neurotic states, mood disorders, antidepressants.

 

Article (pdf)

 

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Materials  

For citation: Kupriyanova I.E., Chuikova K.I., Petrova E.I., Shushpanova T.V., Davaa D.M., Tair Guzyal. Mental disorders in the pathology of liver and biliary tract (literature review). Sibirskii Vestnik Psikhiatrii i Narkologii.2025; 2 (127): 98-108. https://doi.org/10.26617/1810-3111-2025-2(127)-98-108

 

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