Immunological markers for predicting the protracted course of adjustment disorder in women with hypothyroidism

Immunological markers for predicting the protracted course of adjustment disorder in women with hypothyroidism

 

Authors

 

V.B. Nikitina

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

M.F. Belokrylova

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation; Federal State Budgetary Educational Institution of Higher Education “Siberian State Medical University” of the Ministry of Health of the Russian Federation, Tomsk, Russian Federation

N.P. Garganeeva

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation; Federal State Budgetary Educational Institution of Higher Education “Siberian State Medical University” of the Ministry of Health of the Russian Federation, Tomsk, Russian Federation

V.A. Rudnitsky

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

O.E. Perchatkina

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

T.P. Vetlugina

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

M.M. Aksenov

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

N.A. Bokhan

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation; Federal State Budgetary Educational Institution of Higher Education “Siberian State Medical University” of the Ministry of Health of the Russian Federation, Tomsk, Russian Federation

 

https://doi.org/10.26617/1810-3111-2024-3(124)-19-27

 

Journal: Siberian Herald of Psychiatry and Addiction Psychiatry. 2024; 3 (124):  19-27.

 

Abstract

Introduction. The clinical and dynamic aspect of adjustment disorder has not been sufficiently studied. The course of this disorder is influenced by comorbid physical pathology, including thyroid disease. Associations have been established between hypothyroidism and a number of mental disorders that are masked by manifestations caused by a deficiency of thyroid hormones. This complicates the diagnosis of both endocrine and mental pathology, aggravates the course of the disease and delays the recovery period. The nervous, immune and endocrine systems function as a single complex of response to changes in the environment. The significant role of their close relationship in adjustment disorder and other nonpsychotic mental disorders is shown. The interaction between these systems determines many features of the pathogenesis of thyroid diseases, as well as the formation and course of nonpsychotic mental disorders. Objective: to identify immunological markers for predicting the risk of developing a protracted course of adjustment disorder in women with hypothyroidism. Material and Methods. A clinical, psychopathological, hormonal and immunological examination of 58 women with adjustment disorder (ICD-10 code F43.2) and hypothyroidism was conducted. Two groups were formed: Group 1 ‒ with disease duration from 3 weeks to 6 months (n=24); Group 2 ‒ protracted course of adjustment disorder with disease duration from 6 months to 2 years (n=34). All patients were diagnosed with thyroid pathology. Laboratory testing included phenotyping of immunocompetent cells by differentiation clusters using flow cytometry and determination of TSH concentration and free fractions of thyroid hormones using ELISA. All data were statistically processed. Results. Hypothyroidism was detected in all examined women, confirmed by determining the TSH and free fraction of thyroxine (T4) levels in the blood serum. Statistically significant differences in the content of T-lymphocyte subpopulations were established: a decrease in T-helper-inducers (p=0.000164) and an increase in cytotoxic T-lymphocytes (p=0.000288), as well as an increase in the number of lymphocytes with receptors for readiness for apoptosis (p=0.000581) in women with the protracted course of adjustment disorder. These immunity indicators can be considered as markers for predicting the risk of developing the protracted course of adjustment disorder. Conclusion. A method for predicting the protracted course of adjustment disorder in women with hypothyroidism is proposed. This method can be widely used in medicine and health care, that will optimize psychotherapeutic and pharmacological measures in this contingent of patients.

 

Keywords: adjustment disorder, immunity, T-lymphocytes, apoptosis, hypothyroidism, women.

 

Article (pdf)

 

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Materials  

For citation: NikitinaV.B., BelokrylovaM.F., GarganeevaN.P., RudnitskyV.A., PerchatkinaO.E., VetluginaT.P., AksenovM.M., BokhanN.A. Immunologicalmarkersforpredictingtheprotractedcourseofadjustmentdisorderinwomenwithhypothyroidism. Siberian Herald of Psychiatry and Addiction Psychiatry.2024; 3 (124): 19-27. https://doi.org/10.26617/1810-3111-2024-3(124)-19-27

 

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