Effectiveness of cognitive remediation in the treatment of schizophrenia (clinical case)

 

Authors

 

D.A. Petkun

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

V.V. Tiguntsev

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

A.A. Agarkov

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

M.N. Mazur

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

Yu.N. Gorbatsevich

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

Yu.L. Maltseva

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

T.V. Pogorelova

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

 

https://doi.org/10.26617/1810-3111-2024-2(123)-24-31

 

Journal: Siberian Herald of Psychiatry and Addiction Psychiatry. 2024; 2 (123):  24-31.

 

Abstract

In recent decades, neurocognitive deficits were considered in the literature as a third group of symptoms of schizophrenia, in addition to positive and negative ones. Longitudinal studies showed statistically significant decline in working memory and processing speed in first-episode individuals and in at-risk individuals who subsequently experienced a psychotic episode. These manifestations of insufficiency of cognitive functions lead to disruption of social adaptation and reduce the ability of patients to work. For a long time, there was no single examination tool that would cover most higher mental functions, including their qualitative and quantitative aspects: memory, attention and executive skills. The article presented a clinical case of a 23-year-old psychiatric hospital patient with schizophrenia, which occurred with manifestations of neurocognitive deficits in the form of mild disorders of verbal and working memory, moderate impairments of verbal fluency and motor function. The patient received individual cognitive remediation classes with an individual selection of techniques. As a result of motivated medical and neuropsychological tactics, positive dynamics were achieved in the form of an improvement in all cognitive functions.

 

Keywords: schizophrenia, neurocognitive deficit, cognitive remediation, standardized scale “Brief assessment of cognitive functions in patients with schizophrenia”, psychocorrection, rehabilitation.

 

Article (pdf)

 

Contacts

 

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Materials  

 

For citation: Petkun D.A., Tiguntsev V.V., Agarkov A.A., Mazur M.N., Gorbatsevich Yu.N., Maltseva Yu.L., Pogorelova T.V. Effectiveness of cognitive remediation in the treatment of schizophrenia (clinical case). Siberian Herald of Psychiatry and Addiction Psychiatry.2024; 2 (123): 24-31. https://doi.org/10.26617/1810-3111-2024-2(123)-24-31

 

REFERENCES

  1. Kornetov AN, Kornetova EG, Golenkova AV, Kozlova SM, Arzhanik MB, Samoilenko ZhA, Boiko AS, Semke AV. Neurocognitive deficit in the clinical polymorphism of schizophrenia: typology, severity and syndromic overlap. Bulletin of Siberian Medicine. 2019;18(2):107-118. doi: 10.20538/1682-0363-2019-2-107-118 (in Russian).
  2. Kornetov AN, Yazykov KG, Kornetova EG, Fedorenko OYu, Goncharova AA, Semke AV, Ivanova SA, Shmukler AB, Bokhan NA. Normative assessment of cognitive functions using the Brief Assessment of Cognitive Functions in Patients with Schizophrenia (BACS) scale in the Tomsk population: constitutional factors of variability. Siberian Psychological Journal. 2021;82:137-152. doi: 10.17223/17267080/82/8 (in Russian).
  3. Bora E. A comparative meta-analysis of neurocognition in first-degree relatives of patients with schizophrenia and bipolar disorder. Eur Psychiatry. 2017 Sep;45:121-128. doi: 10.1016/j.eurpsy.2017.06.003. Epub 2017 Jul 5. PMID: 28756110.
  4. Sheffield JM, Karcher NR, Barch DM. Cognitive Deficits in Psychotic Disorders: A Lifespan Perspective. Neuropsychol Rev. 2018 Dec;28(4):509-533. doi: 10.1007/s11065-018-9388-2. Epub 2018 Oct 20. PMID: 30343458; PMCID: PMC6475621.
  5. Karyakina MV, Rychkova OV, Shmukler AB. Cognitive impairment in schizophrenia in foreign studies: impairment of individual functions or group syndromes? Contemporary Foreign Psychology. 2021;10(2):8-19. doi: 10.17759/jmfp.2021100201 (in Russian).
  6. Jahshan C, Heaton RK, Golshan S, Cadenhead KS. Course of neurocognitive deficits in the prodrome and first episode of schizophrenia. Neuropsychology. 2010 Jan;24(1):109-120. doi: 10.1037/a0016791. PMID: 20063952; PMCID: PMC2808194.
  7. KornetovaEG, SemkeAV. On the problem of therapy for the first psychotic episode. Siberian Herald of Psychiatry and Addiction Psychiatry. 2009;4(55):17-19 (in Russian).
  8. Kim E, Jang JH, Park HY, Shim G, Hwang JY, Kim SN, Kwon JS. Pharmacotherapy and clinical characteristics of ultra-high-risk for psychosis according to conversion status: a naturalistic observational study. Early Interv Psychiatry. 2012 Feb;6(1):30-7. doi: 10.1111/j.1751-7893.2011.00295.x. Epub 2011 Oct 26. PMID: 22029630.
  9. Zaitseva YuS, Korsakova NK, Gurovich IYa. Neurocognitive functioning in the early stages of schizophrenia and cognitive remediation. Social and Clinical Psychiatry. 2013;23(4):76-82 (in Russian).
  10. Vita A, Barlati S, Ceraso A, Nibbio G, Ariu C, Deste G, Wykes T. Effectiveness, core elements, and moderators of response of cognitive remediation for schizophrenia: a systematic review and meta-analysis of randomized clinical trials. JAMA Psychiatry. 2021 Aug 1;78(8):848-858. doi: 10.1001/jamapsychiatry.2021.0620. PMID: 33877289; PMCID: PMC8058696.
  11. McGurk SR, Twamley EW, Sitzer DI, McHugo GJ, Mueser KT. A meta-analysis of cognitive remediation in schizophrenia. Am J Psychiatry. 2007 Dec;164(12):1791-802. doi: 10.1176/appi.ajp.2007. 07060906. PMID: 18056233; PMCID: PMC3634703.
  12. Kornetova EG, Goncharova AA, Dmitrieva EG, Arzhanik AA, Kornetov AN, Semke AV. The influence of clinical and therapeutic indicators on the severity of neurocognitive deficits in patients with schizophrenia. Bulletin of Siberian Medicine. 2020; 19(3):36-43. doi: 10.20538/1682-0363-2020-3-36-43(in Russian).
  13. Tsukarzi ÉÉ. Efficacy of aripiprazole (amdoal) in the long-term treatment of schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2013;113(3):94‑96 (in Russian).
  14. Kholmogorova AB, Garanyan NG, Dolnikova AA, Shmukler AB. Cognitive and social skills training (CSST) program for patients with schizophrenia. Social and Clinical Psychiatry. 2007;17(4):67-77 (in Russian).
  15. Tsvetkova LS. Neuropsychology of counting, writing and reading: impairment and recovery. Manual. Moscow: Bukinist Publishing House, 2005. 360 (in Russian).
  16. Logvina EN. Neurosimulator. Games and exercises. Methodological manuals with illustrations. Ekaterinburg: ArtesPrint Publishing House, 2022:90 (in Russian).
  17. Nevzorova AA, Chabanenko VF. Neuropsychological album on the development of cognitive abilities. Moscow: Galaktika Publishing House, 2022. 68 (in Russian).
  18. Ryzhova IA. Cognitive training as a psycho-correctional method in psychiatry. Medical Psychology in Russia. 2017;5(46). [Electronic resource]. URL: http://mprj.ru (19.01.2024) (in Russian).