Humoral factors of anabolic and catabolic balance in women with depressive disorders

Humoral factors of anabolic and catabolic balance in women with depressive disorders

 

Authors

 

L.A. Levchuk

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

D.R. Biktimirov

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

E.V. Gutkevich

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

O.V. Roshchina

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

S.N. Vasilieva

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

T.V. Kazennykh

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

O.E. Perchatkina

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

M.M. Aksenov

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russian Federation

 

https://doi.org/10.26617/1810-3111-2024-1(122)-18-26

 

Journal: Siberian Herald of Psychiatry and Addiction Psychiatry. 2024; 1 (122):  18-26.

 

Abstract

Relevance of the study of depressive disorders and depression-like conditions is determined by the high prevalence of these disorders in all age groups and the increasing impact of depressive disorders on the level of social functioning and quality of life of society. The findings of biological studies on affective pathology are very ambiguous and relate to the research on various aspects of the functioning of homeostatic systems. Changes in the functioning of the hypothalamic-pituitary-adrenal system and the sympathoadrenal system that accompany depressive disorders are due to the physiological functioning these systems as mediators of the body's response to stressors. Objective: to study the content of cortisol and dehydroepiandrosterone sulfate (DHEAS) in the blood serum of women with depressive disorders. Material and Methods. The study sample (n=61) was formed from women aged 18-60 years who were treated at the Affective and Borderline States Departments of the clinic of Mental Health Research Institute of Tomsk National Research Medical Center. In accordance with the ICD-10 criteria, the following were diagnosed: current depressive episode within a single depressive episode (F32) and recurrent depressive disorder (F33) were found in 24 patients; adjustment disorder with a predominance of depressive reactions (F43.2) were revealed in 37 patients. The control group consisted of mentally and somatically healthy women (n=29), who matched the sex and age of the patients being examined, who did not have chronic diseases and were not under medical observation, and who had no signs of acute infectious diseases at the time of the examination. Patients in the research sample and women from the control group were divided depending on the age factor: young (under 39 years old) and mature (over 40 years old) ages. Laboratory testing included determination of the concentration of cortisol and dehydroepiandrosterone sulfate in the blood serum using enzyme immunoassay. Statistical data processing was carried out using the SPSS 26.0 software package for Windows. Results. The study found that increasing age was associated with a statistically significant (p=0.012) decrease in the DHEAS content in the blood serum of patients with adjustment disorder and a predominance of depressive reactions. In addition, in patients with adjustment disorder and a predominance of depressive reactions under the age of 39 years, a statistically significantly increased level of cortisol was revealed in comparison with mentally healthy women (p=0.015) and patients with depressive disorders (p=0.039). Pairwise comparisons of the study groups of women above the age of 40 years demonstrated a statistically significantly (p=0.005) increased level of cortisol in patients with adjustment disorder of adulthood compared to mentally healthy women. Conclusion. Thus, the study of the humoral factors in women with depressive disorders revealed disturbances in anabolic and catabolic processes, changes in the hypothalamic-pituitary-adrenal system, which were likely due to the physiological functioning this system as a mediator of the body’s response to stressors.

 

Keywords: depressive disorders, women, cortisol, dehydroepiandrosterone sulfate.

 

Article (pdf)

 

Contacts

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Materials 

For citation: LevchukL.A., BiktimirovD.R., GutkevichE.V., RoshchinaO.V., VasilievaS.N., KazennykhT.V., PerchatkinaO.E., AksenovM.M. Humoralfactorsofanabolicandcatabolicbalanceinwomenwithdepressivedisorders. Siberian Herald of Psychiatry and Addiction Psychiatry.2024; 1 (122): 18-26. https://doi.org/10.26617/1810-3111-2024-1(122)-18-26

 

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