Mild cognitive decline with psychopathological symptoms (literature review)

 

Authors

 

A.A. Melnik

Federal State Budgetary Educational Institution of Higher Education “Ural State Medical University” of the Ministry of Health of the Russian Federation, Yekaterinburg, Russian Federation

K.P. Dick

Federal State Budgetary Educational Institution of Higher Education “Ural State Medical University” of the Ministry of Health of the Russian Federation, Yekaterinburg, Russian Federation

O.V. Serdyuk

State Budgetary Health Institution of the Sverdlovsk Region “Sverdlovsk Regional Clinical Psychiatric Hospital”, Yekaterinburg, Russian Federation

A.P. Sidenkova

Federal State Budgetary Educational Institution of Higher Education “Ural State Medical University” of the Ministry of Health of the Russian Federation, Yekaterinburg, Russian Federation

A.S. Romashova

Federal State Budgetary Educational Institution of Higher Education “Ural State Medical University” of the Ministry of Health of the Russian Federation, Yekaterinburg, Russian Federation

A.K. Khatskevich

Federal State Budgetary Educational Institution of Higher Education “Ural State Medical University” of the Ministry of Health of the Russian Federation, Yekaterinburg, Russian Federation

L.A. Salkova

Federal State Budgetary Educational Institution of Higher Education “Ural State Medical University” of the Ministry of Health of the Russian Federation, Yekaterinburg, Russian Federation

A.S. Fomina

Federal State Budgetary Educational Institution of Higher Education “Ural State Medical University” of the Ministry of Health of the Russian Federation, Yekaterinburg, Russian Federation

Yu.A. Agafonova

State Autonomous Healthcare Institution of the Sverdlovsk Region “Sverdlovsk Regional Center for the Prevention and Control of AIDS”, Yekaterinburg, Russian Federation

 

https://doi.org/10.26617/1810-3111-2023-2(119)-70-77

 

Journal: Siberian Herald of Psychiatry and Addiction Psychiatry. 2023; 2 (119):  70-77.

 

Abstract

Mild cognitive impairment in some cases can be a criterion for predicting more severe cognitive impairment. The review article is devoted to the problem of mild cognitive decline (Mild Cognitive Impairment, MCI): its prevalence, typology, and pathogenesis. The main attention is paid to the issues of psychopathological symptoms in the structure of mild cognitive decline, the mechanisms of their formation and clinical, pathogenetic and prognostic significance. The research materials were scientific publications on the topic of the work. The general scientific method is applied: analysis of modern scientific domestic and foreign literature on the research problem. The results were obtained, indicating an unfavorable prognostic value of MCI, especially in combination with psychopathological symptoms, determined by a high risk of transformation into dementia and a significant decrease in the functional activity of the patient at the pre-dementia stage.

 

Keywords: mild cognitive impairment, psychopathological symptoms, predementia cognitive disorders, old age.

 

Article (pdf)

 

Contacts

This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Materials  

For citation: Melnik A.A., Dick K.P., Serdyuk O.V., Sidenkova A.P., Romashova A.S., Khatskevich A.K., Salkova L.A., Fomina A.S., Agafonova Yu.A. Mild cognitive decline with psychopathological symptoms (literature review). Siberian Herald of Psychiatry and Addiction Psychiatry. 2023; 2 (119): 70-77. https://doi.org/10.26617/1810-3111-2023-2(119)-70-77.

 

REFERENCES

  1. Myakotnykh VS, Ostapchuk ES, Sidenkova AP. Age and gender aspects of cerebrovascular pathology and cognitive disorders. Moscow: Triumph Publishing House, 2020:291. DOI:10.32986/978-5-93673-307-9-12-2020(in Russian).
  2. Serdyuk OV, Sidenkova AP, KhilyukDA. Clinical and dynamic features and prognostic value of non-cognitive psychopathological symptoms in mild cognitive impairment (MCI). Psikhiatriya.2021;19(2):17-28. doi: 10.30629/2618-6667-2021-19-2-17-28 (in Russian).
  3. GavrilovaSI. Pre-dementianeurocognitivedisorder: diagnosticandtherapeuticaspects. V.M. Bekhterev Review of Psychiatry and Medical Psychology. 2018;(1):89-98 (in Russian).
  4. Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, Nordberg A, Bäckman L, Albert M, Almkvist O, Arai H, Basun H, Blennow K, de Leon M, DeCarli C, Erkinjuntti T, Giacobini E, Graff C, Hardy J, Jack C, Jorm A, Ritchie K, van Duijn C, Visser P, Petersen RC. Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med. 2004 Sep;256(3):240-6. doi: 10.1111/j.1365-2796.2004.01380.x. PMID: 15324367.
  5. Palmer K, Bäckman L, Winblad B, Fratiglioni L. Mild cognitive impairment in the general population: occurrence and progression to Alzheimer disease. Am J Geriatr Psychiatry. 2008 Jul;16(7):603-11. doi: 10.1097/JGP.0b013e3181753a64. PMID: 18591580.
  6. Petersen RC, Aisen P, Boeve BF, Geda YE, Ivnik RJ, Knopman DS, Mielke M, Pankratz VS, Roberts R, Rocca WA, Weigand S, Weiner M, Wiste H, Jack CR Jr. Mild cognitive impairment due to Alzheimer disease in the community. Ann Neurol. 2013 Aug;74(2):199-208. doi: 10.1002/ana.23931
  7. Dubois B, Hampel H, Feldman HH et al. Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria. Alzheimers Dement. 2016 Mar;12(3):292-323. doi: 10.1016/j.jalz.2016.02.002. PMID: 27012484; PMCID: PMC6417794.
  8. Roberts RO, Geda YE, Knopman DS, Cha RH, Pankratz VS, Boeve BF, Tangalos EG, Ivnik RJ, Rocca WA, Petersen RC. The incidence of MCI differs by subtype and is higher in men: the Mayo Clinic Study of Aging. Neurology. 2012 Jan 31;78(5):342-51. doi: 10.1212/WNL. 0b013e3182452862. Epub 2012 Jan 25. PMID: 22282647; PMCID: PMC3280046.
  9. Weintraub S, Besser L, Dodge HH et al. Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS). Alzheimer Dis Assoc Disord. 2018 Jan-Mar;32(1):10-17. doi: 10.1097/WAD. 0000000000000223. PMID: 29240561; PMCID: PMC5821520.
  10. Grundman M, Petersen RC, Ferris SH, et al. Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol. 2004 Jan;61(1):59-66. doi: 10.1001/archneur.61.1.59. PMID: 14732621.
  11. Golomb J, Kluger A, Ferris SH. Mild cognitive impairment: historical development and summary of research. Dialogues Clin Neurosci. 2004 Dec;6(4):351-67. doi: 10.31887/DCNS. 2004.6.4/jgolomb. PMID: 22034453; PMCID: PMC3181818.
  12. Katz DI, Bernick C, Dodick DW et al. National Institute of Neurological Disorders and Stroke Consensus Diagnostic Criteria for Traumatic Encephalopathy Syndrome. Neurology. 2021 May 4;96(18):848-863. doi: 10.1212/WNL.0000000000011850. Epub 2021 Mar 15. PMID: 33722990; PMCID: PMC8166432.
  13. Verghese PB, Castellano JM, Holtzman DM. Apolipoprotein E in Alzheimer's disease and other neurological disorders. Lancet Neurol. 2011 Mar;10(3):241-52. doi: 10.1016/S1474-4422(10)70325-2. PMID: 21349439; PMCID: PMC3132088.
  14. Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, Ritchie K, Rossor M, Thal L, Winblad B. Current concepts in mild cognitive impairment. Arch Neurol. 2001 Dec;58(12):1985-92. doi: 10.1001/archneur.58.12.1985. PMID: 11735772.
  15. Manly JJ, Tang MX, Schupf N, Stern Y, Vonsattel JP, Mayeux R. Frequency and course of mild cognitive impairment in a multiethnic community. Ann Neurol. 2008 Apr;63(4):494-506. doi: 10.1002/ana.21326. PMID: 18300306; PMCID: PMC2375143.
  16. Katz MJ, Lipton RB, Hall CB, Zimmerman ME, Sanders AE, Verghese J, Dickson DW, Derby CA. Age-specific and sex-specific prevalence and incidence of mild cognitive impairment, dementia, and Alzheimer dementia in blacks and whites: a report from the Einstein Aging Study. Alzheimer Dis Assoc Disord. 2012 Oct-Dec;26(4):335-43. doi: 10.1097/WAD.0b013e31823dbcfc. PMID: 22156756; PMCID: PMC3334445.
  17. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, Phelps CH. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011 May;7(3):270-9. doi: 10.1016/j.jalz.2011.03.008. Epub 2011 Apr 21. PMID: 21514249; PMCID: PMC3312027.
  18. Manly JJ, Bell-McGinty S, Tang MX, Schupf N, Stern Y, Mayeux R. Implementing diagnostic criteria and estimating frequency of mild cognitive impairment in an urban community. Arch Neurol. 2005 Nov;62(11):1739-46. doi: 10.1001/archneur. 62.11.1739. PMID: 16286549.
  19. Busse A, Hensel A, Gühne U, Angermeyer MC, Riedel-Heller SG. Mild cognitive impairment: long-term course of four clinical subtypes. Neurology. 2006 Dec 26;67(12):2176-85. doi: 10.1212/01.wnl.0000249117.23318.e1. PMID: 17190940.
  20. Kern S, Zetterberg H, Kern J, Zettergren A, Waern M, Höglund K, Andreasson U, Wetterberg H, Börjesson-Hanson A, Blennow K, Skoog I. Prevalence of preclinical Alzheimer disease: Comparison of current classification systems. Neurology. 2018 May 8;90(19):e1682-e1691. doi: 10.1212/WNL. 0000000000005476. Epub 2018 Apr 13. PMID: 29653987; PMCID: PMC5952969.
  21. Sheikh F, Ismail Z, Mortby ME et al. Prevalence of mild behavioral impairment in mild cognitive impairment and subjective cognitive decline, and its association with caregiver burden. Int Psychogeriatr. 2018 Feb;30(2):233-244. doi: 10.1017/S104161021700151X. Epub 2017 Sep 7. PMID: 28879833.
  22. Lopez OL, Jagust WJ, DeKosky ST, Becker JT, Fitzpatrick A, Dulberg C, Breitner J, Lyketsos C, Jones B, Kawas C, Carlson M, Kuller LH. Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1. Arch Neurol. 2003 Oct;60(10):1385-9. doi: 10.1001/archneur.60.10.1385. PMID: 14568808.
  23. Graham JE, Rockwood K, Beattie BL, Eastwood R, Gauthier S, Tuokko H, McDowell I. Prevalence and severity of cognitive impairment with and without dementia in an elderly population. Lancet. 1997 Jun 21;349(9068):1793-6. doi: 10.1016/S0140-6736(97)01007-6. PMID: 9269213.
  24. Petersen RC, Roberts RO, Knopman DS, Geda YE, Cha RH, Pankratz VS, Boeve BF, Tangalos EG, Ivnik RJ, Rocca WA. Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging. Neurology. 2010 Sep 7;75(10):889-97. doi: 10.1212/WNL.0b013e3181f11d85
  25. Petersen R.C. How early can we diagnose Alzheimer disease (and is it sufficient)? The 2017 Wartenberg lecture Neurology Aug 2018, 91 (9) 395-402; doi: 10.1212/WNL.0000000000006088
  26. Petersen RC, Morris JC. Conceptual overview. In: Mild cognitive impairment: aging to Alzheimer`s disease. New York: Oxford University Press, 2003: 1-14 URL: https://psycnet.apa.org/record/2003-04753-001
  27. Di Carlo A, Lamassa M, Baldereschi M, Inzitari M, Scafato E, Farchi G, Inzitari D. CIND and MCI in the Italian elderly: frequency, vascular risk factors, progression to dementia. Neurology. 2007 May 29;68(22):1909-16. doi: 10.1212/01.wnl.0000263132.99055.0d. PMID: 17536047.
  28. Aerts L, Heffernan M, Kochan NA, Crawford JD, Draper B, Trollor JN, Sachdev PS, Brodaty H. Effects of MCI subtype and reversion on progression to dementia in a community sample. Neurology. 2017 Jun 6;88(23):2225-2232. doi: 10.1212/WNL.0000000000004015. Epub 2017 May 10. PMID: 28490651.
  29. Palmer K, Berger AK, Monastero R, Winblad B, Bäckman L, Fratiglioni L. Predictors of progression from mild cognitive impairment to Alzheimer disease. Neurology. 2007 May 8;68(19):1596-602. doi: 10.1212/01.wnl.0000260968.92345.3f. PMID: 17485646.
  30. Mariani E, Monastero R, Mecocci P. Mild cognitive impairment: a systematic review. J Alzheimers Dis. 2007 Aug;12(1):23-35. doi: 10.3233/jad-2007-12104. PMID: 17851192.
  31. Ganguli M, Dodge HH, Shen C, DeKosky ST. Mild cognitive impairment, amnestic type: an epidemiologic study. Neurology. 2004 Jul 13;63(1):115-21. doi: 10.1212/01.wnl.0000132523.27540.81. PMID: 15249620.
  32. Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol. 2006 Oct;112(4):389-404. doi: 10.1007/s00401-006-0127-z. Epub 2006 Aug 12. PMID: 16906426; PMCID: PMC3906709.
  33. Alafuzoff I, Parkkinen L, Al-Sarraj S et al. Assessment of alpha-synuclein pathology: a study of the BrainNet Europe Consortium. J Neuropathol Exp Neurol. 2008 Feb;67(2):125-43. doi: 10.1097/nen.0b013e3181633526. PMID: 18219257.
  34. Mandelkow EM, Mandelkow E. Biochemistry and cell biol*ogy of tau protein in neurofibrillary degeneration. Cold Spring Harb Perspect Med. 2012 Jul;2(7):a006247. doi: 10.1101/cshperspect.a006247. PMID: 22762014; PMCID: PMC3385935.
  35. Cummings JL. The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology. 1997 May;48(5 Suppl 6):S10-6. doi: 10.1212/wnl.48.5_suppl_6.10s. PMID: 9153155.
  36. Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol. 1991 Oct;30(4):572-80. doi: 10.1002/ana.410300410. PMID: 1789684.
  37. Feldman H, Scheltens P, Scarpini E, Hermann N, Mesenbrink P, Mancione L, Tekin S, Lane R, Ferris S. Behavioral symptoms in mild cognitive impairment. Neurology. 2004 Apr 13;62(7):1199-201. doi: 10.1212/01.wnl.0000118301.92105.ee. Erratum in: Neurology. 2004 Aug 24;63(4):764. PMID: 15079026.
  38. Sidenkova AP. Clinical diversity of facultative psychotic disorders in Alzheimer's disease. Siberian Herald of Psychiatry and Addiction Psychiatry. 2009;1(52):104-107 (in Russian).
  39. Ownby RL, Crocco E, Acevedo A, John V, Loewenstein D. Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry. 2006 May;63(5):530-8. doi: 10.1001/archpsyc.63.5.530. PMID: 16651510; PMCID: PMC3530614.
  40. Black W, Almeida OP. A systematic review of the association between the behavioral and psychological symptoms of dementia and burden of care. Int Psychogeriatr. 2004 Sep;16(3):295-315. doi: 10.1017/s1041610204000468. PMID: 15559754.
  41. Feldman H, Scheltens P, Scarpini E, Hermann N, Mesenbrink P, Mancione L, Tekin S, Lane R, Ferris S. Behavioral symptoms in mild cognitive impairment. Neurology. 2004 Apr 13;62(7):1199-201. doi: 10.1212/01.wnl.0000118301.92105.ee. Erratum in: Neurology. 2004 Aug 24;63(4):764. PMID: 15079026.
  42. SemkeAV, SidenkovaAP. Analysis of the prevalence and consequences of cognitive disorders in persons of older age groups in the Sverdlovsk Region. Siberian Herald of Psychiatry and Addiction Psychiatry. 2011;6(69):20-24 (in Russian).
  43. Modrego PJ, Ferrández J. Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort study. Arch Neurol. 2004 Aug;61(8):1290-3. doi: 10.1001/archneur.61.8.1290. PMID: 15313849.
  44. Garganeeva NP, Shakhurova NI, Schastnyy ED. Depressive spectrum disorders in later life: a common problem in therapeutic and psychiatric practice. Siberian Herald of Psychiatry and Addiction Psychiatry. 2009;3:78-83 (in Russian).
  45. Hwang JY, Byun MS, Choe YM, Lee JH, Yi D, Choi JW, Hwang SH, Lee YJ, Lee DY; KBASE Research Group. Moderating effect of APOE ε4 on the relationship between sleep-wake cycle and brain β-amyloid. Neurology. 2018 Mar 27;90(13): e1167-e1173. doi: 10.1212/WNL.0000000000005193. Epub 2018 Feb 28. PMID: 29490913.
  46. Rakhmazova LD, Agarkov AA, Vasilyeva NA, Petrachkov IV, Pogorelova TV. Clinical and social adaptation of patients with psychosis and dementia. Siberian Herald of Psychiatry and Addiction Psychiatry. 2014;2(83):8-13 (in Russian).
  47. Sidenkova AP. Characteristics of anxiety in patients of older age groups with different types of mild cognitive disorder. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(11):45‑50. https://doi.org/10.17116/jnevro201711711145-50(in Russian).
  48. KupriyanovaIE, SemkeGV, GaleevaKV. Depressive and anxiety disorders in arterial hypertension (review of foreign literature). Siberian Herald of Psychiatry and Addiction Psychiatry. 2010;1(58):48-51 (in Russian).
  49. Liew TM. Neuropsychiatric symptoms in cognitively normal older persons, and the association with Alzheimer’s and non-Alzheimer’s dementia. Alz Res Therapy March 2020;12(1). doi: 10.1186/s13195-020-00604-7