Interrelationship between cognitive status and antisaccade parameters in patients with schizophrenia
Authors
D.A. Shvaiko
Federal State Autonomous Educational Institution of Higher Education Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation
M.G. Yanushko
National Medical Research Center for Psychiatry and Neurology named after V.M. Bekhterev of the Ministry of Health of Russia, St. Petersburg, Russian Federation
M.V. Shamanina
National Medical Research Center for Psychiatry and Neurology named after V.M. Bekhterev of the Ministry of Health of Russia, St. Petersburg, Russian Federation
M.V. Ivanov
National Medical Research Center for Psychiatry and Neurology named after V.M. Bekhterev of the Ministry of Health of Russia, St. Petersburg, Russian Federation
https://doi.org/10.26617/1810-3111-2022-4(117)-22-32
Journal: Siberian Herald of Psychiatry and Addiction Psychiatry. 2022; 4 (117): 22-32
Abstract
Background. The structures that make up the oculomotor system are inextricably linked with cognitive functions that suffer in schizophrenia, which creates characteristic features in deviations in the characteristics of oculomotor response (hereinafter referred to as OMR). In this regard, it is of interest to study visual coordination in the form of tracking eye movements (saccades), since saccadic disturbances are a frequent occurrence in mental disorders. The search and description of the characteristic signs of OMR in schizophrenia can serve as an accessible neurophysiological informative marker of the patient's condition. Objective. Identification of the features of antisaccade reactions and determination of the relationship between cognitive status and antisaccade parameters in patients with schizophrenia. Tasks. To analyze the parameters of antisaccades in patients with schizophrenia, taking into account age, based on the correlation analysis of the parameters of antisaccades and the results of cognitive tests, to identify the clinical and dynamic characteristics of the current mental state of patients depending on the severity of cognitive impairment in positive and negative symptoms. Materials and Methods. Based on the Department of Biological Therapy of Mentally Ill of National Medical Research Center for Psychiatry and Neurology named after V.M. Bekhterev of the Ministry of Health of Russia, 76 patients (mean age 30.6 years) with paranoid schizophrenia (F20.0) diagnosed according to ICD-10 in a state of therapeutic remission were examined. Video oculography was used to record OMR parameters, and the Battery of Brief Assessment of Cognition in Schizophrenia (BACS) was used to assess cognitive status. Results. An increase in the latent period of saccades by an easily predictable stimulus in the Gap temporal pattern can be considered as a valid predictor of the detection of executive dysfunction. It was found that the efficiency of antisaccade execution in the temporal scheme Step correlated negatively with the speed of information processing and the severity of positive and negative symptoms according to the PANSS scale. Conclusion. The findings and the main provisions in the scientific literature on the biological substrate of cognitive impairments and oculomotor responses allow us to conclude that the efficiency in performing antisaccades characterizes the current state of the patient in terms of the severity of negative symptoms and cognitive impairments.
Keywords: schizophrenia, oculomotor responses, cognitive impairment, saccades, antisaccades, negative symptoms, positive symptoms.
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Materials
For citation: Shvaiko D.A., Yanushko M.G., Shamanina M.V., Ivanov M.V. Interrelationship between cognitivestatus and antisaccade parameters in patients with schizophrenia.Siberian Herald of Psychiatry and Addiction Psychiatry.2022; 4 (117): 22-32. https://doi.org/10.26617/1810-3111-2022-4(117)-22-32
REFERENCES
- Green MF. Cognitive impairment and functional outcome in schizophrenia and bipolar disorder. J Clin Psychiatry. 2006;67 Suppl 9:3-8; discussion 36-42. PMID: 16965182.
- YanushkoMG, IvanovMV, SorokinaAV. Cognitive impairments in endogenous psychosis: modern ideas in the light of the dimensional approach. Social and Clinical Psychiatry. 2014;24(1):90-95(in Russian).
- Barabanshchikov VA, Zhegallo AV. Eyetracking: Methods for registering eye movements in psychological research and practice. Moscow: Publishing House Kogito-center, 2014:128(in Russian).
- VitVV. The structure of the human visual system. Moscow: Astroprint Publishing House, 2003:727(in Russian).
- Purves D, Augustine G, Fitzpatrick D, Hall WC, LaMantia A, Mooney R, White LE. Neuroscience. 5th Edition. Oxford University Press, 2012. 759 p.
- Honea R, Crow TJ, Passingham D, Mackay CE. Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. Am J Psychiatry. 2005 Dec;162(12):2233-45. doi: 10.1176/appi.ajp.162.12.2233. PMID: 16330585.
- Kim IH, Rossi MA, Aryal DK, Racz B, Kim N, Uezu A, Wang F, Wetsel WC, Weinberg RJ, Yin H, Soderling SH. Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine. Nat Neurosci. 2015 Jun;18(6):883-91. doi: 10.1038/nn.4015. Epub 2015 May 4. PMID: 25938885; PMCID: PMC4459733.
- Bittencourt J, Velasques B, Teixeira S, Basile LF, Salles JI, Nardi AE, Budde H, Cagy M, Piedade R, Ribeiro P. Saccadic eye movement applications for psychiatric disorders. Neuropsychiatr Dis Treat. 2013;9:1393-409. doi: 10.2147/NDT.S45931. Epub 2013 Sep 16. PMID: 24072973; PMCID: PMC3783508.
- Damilou A, Apostolakis S, Thrapsanioti E, Theleritis C, Smyrnis N. Shared and distinct oculomotor function deficits in schizophrenia and obsessive compulsive disorder. Psychophysiology. 2016 Jun;53(6):796-805. doi: 10.1111/psyp.12630. Epub 2016 Feb 23. PMID: 26914941.
- Morita K, Miura K, Fujimoto M, Yamamori H, Yasuda Y, Iwase M, Kasai K, Hashimoto R. Eye movement as a biomarker of schizophrenia: Using an integrated eye movement score. Psychiatry Clin Neurosci. 2017 Feb;71(2):104-114. doi: 10.1111/pcn.12460. Epub 2016 Nov 3. PMID: 27673731.
- Keefe RS, Harvey PD, Goldberg TE, Gold JM, Walker TM, Kennel C, Hawkins K. Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS). Schizophr Res. 2008 Jul;102(1-3):108-15. doi: 10.1016/j.schres.2008.03.024. Epub 2008 May 20. PMID: 18495435.
- Keefe RS, Goldberg TE, Harvey PD, Gold JM, Poe MP, Coughenour L. The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery. Schizophr Res. 2004 Jun 1;68(2-3):283-97. doi: 10.1016/j.schres.2003.09.011. PMID: 15099610.
- Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13(2):261-76. doi: 10.1093/schbul/13.2.261. PMID: 3616518.
- Opler MGA, Yavorsky C, Daniel DG. Positive and Negative Syndrome Scale (PANSS) Training: Challenges, Solutions, and Future Directions. Innov Clin Neurosci. 2017 Dec 1;14(11-12):77-81. PMID: 29410941; PMCID: PMC5788255.
- SarkisyanGR, GurovichIYa, KifRS. Normative data for the Russian population and standardization of the scale “Brief Assessment of Cognitive Functions in Patients with Schizophrenia”(BACS). Social and Clinical Psychiatry. 2010;20(3):13-19(in Russian).
- Kornetov AN, Yazykov KG, Kornetova EG, Fedorenko OYu, Goncharova AA, Semke AV, Ivanova SA, Shmukler A B, Bokhan NA. Normative assessment of cognitive functions on the scale “Brief Assessment of Cognitive Functions in Patients with Schizophrenia”(BACS) in the Tomsk population: constitutional factors of variability. Siberian Psychological Journal. 2021;82:137-152(in Russian).
- MastitskySE, ShitikovVK. Statistical Analysis and Data Visualization with R. E-book. URL: http://r-analytics.blogspot.com (in Russian).
- YunkerovVI, GrigorievSG, RezvantsevMV. Mathematical and statistical processing of medical research data. St. Petersburg: Publishing House Military Medical Academy. 2002:318(in Russian).
- Wickham H. ggplot2: elegant graphics for data analysis. Second Edition. Springer. Houston, Texas, USA, 2016:260.
- Broerse A, Crawford TJ, den Boer JA. Differential effects of olanzapine and risperidone on cognition in schizophrenia? A saccadic eye movement study. J Neuropsychiatry Clin Neurosci. 2002 Fall;14(4):454-60. doi: 10.1176/jnp.14.4.454. PMID: 12426415.
- ZaitsevaYuS, KorsakovaNK, GurovichIYa. Neurocognitive functioning in the early stages of schizophrenia and cognitive remediation. Social and Clinical Psychiatry. 2013;23(4):76-8(in Russian).
- Keefe RS, Eesley CE, Poe MP. Defining a cognitive function decrement in schizophrenia. Biol Psychiatry. 2005 Mar 15;57(6):688-91. doi: 10.1016/j.biopsych.2005.01.003. PMID: 15780858.
- Leigh RJ, Zee DS. The neurology of eye movements. 3rd edition. Oxford University Press, 1999:654.