Siberian Herald of Psychiatry and Addiction Psychiatry no. 4, 2017
Reaction of neurons of inner layers of the retina on combined influence of ionizing radiation and bright light
Authors
A. V. Potapov
Siberian State Medical University, Tomsk, Russia
A. V. Gerasimov
Siberian State Medical University, Tomsk, Russia
E. Yu. Varakuta
Siberian State Medical University, Tomsk, Russia
A. V. Solonsky
Siberian State Medical University, Tomsk, Russia
Y. O. Sverdeva
Siberian State Medical University, Tomsk, Russia
E. Yu. Anikina
Siberian State Medical University, Tomsk, Russia
L. R. Mustafina
Siberian State Medical University, Tomsk, Russia
T. V. Shushpanova
Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia
S. V. Logvinov
Siberian State Medical University, Tomsk, Russia
https://doi.org/10.26617/1810-3111-2017-4(97)-10-14
Journal: Siberian Herald of Psychiatry and Addiction Psychiatry. 2017; 4 (97): 10–14.
Abstract
Objectives. Structural changes of the inner nuclear and ganglion cell layers of the retina in white mongrel male rats (n = 60) were studied with the combined effects of ionizing radiation at a dose of 5, 10, 15 Gr and light (3500 Lux, 48 h). Results. The study showed that the reactions of neurons of the inner nuclear and ganglionic layers after the X-ray and combined layers depended on the dose, such changes as vacuolization and destruction of organelles occurred and are most pronounced when combined with ionizing radiation at a dose of 15 Gr and light. An analysis of the number of hyperchromic neurons of the internal nuclear and ganglionic layers showed that after the end of exposure to ionizing radiation at doses of 10, 15 Gr, the amount of hyperchromic cells was much larger than the control values (p <0.05). After the end of the combined irradiation of ionizing radiation at a dose of 10, 15 Gr and high-intensity light, this index decreased, that indicated the failure of compensatory and adaptive mechanisms with an increase in the radiation dose and the intensification of the destruction processes.
Keywords: protein oxidative modification, lipid peroxidation, blood plasma, antialcohol therapy, alcoholism.
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Materials