Идентификация биомаркеров шизофрении с помощью методов масс-спектрометрии (обзор литературы)

Идентификация биомаркеров шизофрении с помощью методов масс-спектрометрии (обзор литературы)

 

Авторы

 

А.Б. Языкова

ФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава России, Нижний Новгород, Россия

А.Э. Новоселова

ФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава России, Нижний Новгород, Россия

И.Е. Царьков

ФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава России, Нижний Новгород, Россия

Т.В. Жиляева

ФГБОУ ВО «Приволжский исследовательский медицинский университет» Минздрава России, Нижний Новгород, Россия; ФГБУ «Национальный медицинский исследовательский центр психиатрии и неврологии

им. В.М. Бехтерева» Минздрава России, Санкт-Петербург, Россия

 

https://doi.org/10.26617/1810-3111-2023-1(118)-71-81

 

Журнал:Сибирский вестник психиатрии и наркологии. 2023; 1(118): 71-81.

 

Реферат

Цель:анализ результатов современных отечественных и зарубежных исследований биологических маркеров шизофрении с помощью методов масс-спектрометрии, выделение основных перспективных направлений исследований в области метаболомики и протеомики при шизофрении, обсуждение принципов работы и современных возможностей различных модификаций масс-спектрометров при анализе протеомного и метаболомного составов биологических жидкостей пациентов, страдающих шизофренией. В результате анализа данных литературы с обобщением имеющихся в настоящее время результатов оригинальных исследований, систематических обзоров и метаанализов представлены сведения об основных группах биомаркеров и ведущих механизмах патогенеза, наиболее активно изучаемых в настоящее время при шизофрении методами масс-спектрометрии, а также об ограничениях метаболомики при изучении этого заболевания.

 

Ключевые слова: шизофрения, биологические маркеры, метаболомика, протеомика, масс-спектрометрия.

 

Статья (pdf)

 

Связь с автором

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Дополнительные материалы

 

Для цитирования: Языкова А.Б., Новоселова А.Э., Царьков И.Е., Жиляева Т.В. Идентификация биомаркеров шизофрении с помощью методов масс-спектрометрии (обзор литературы). Сибирский вестник психиатрии и наркологии. 2023. № 1 (118). С. 71-81 https://doi.org/10.26617/1810-3111-2023-1(118)-71-81

 

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